Assay Detail
Functional
CHEMBL958593
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Cytotoxicity against human KB cells after 72 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.37 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464705 | NELUMAL A | — | 1 | 5.58 |
| CHEMBL464449 | NELUMOL A | — | 1 | 5.52 |
| CHEMBL450637 | — | — | 1 | 5.28 |
| CHEMBL464893 | — | — | 1 | 5.11 |
| CHEMBL464706 | — | — | 1 | - |
| CHEMBL464891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464705 | NELUMAL A | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL464449 | NELUMOL A | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL450637 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL464893 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL464706 | — | IC50 | = | 860000.0 | nM | - |
| CHEMBL464891 | — | IC50 | = | 640000.0 | nM | - |