Assay Detail

CHEMBL958736

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Binding

Inhibition of BACE1

ChEMBL ↗

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Target

Beta-secretase 1 (CHEMBL4822) ↗

Open DB target context

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Beta-secretase 1 (CHEMBL4822) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Beta-secretase 1

CHEMBL4822

Anchored from Assay target.

Protein identity Beta-secretase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Intermediate

Target

Beta-secretase 1 (CHEMBL4822) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Recent developments in fragment-based drug discovery.

Congreve M, Chessari G, Tisi D, Woodhead AJ.
J Med Chem (2008) 51 : 3661 -3680
PubMed 18457385 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	2.70	2.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL62083	—	—	1	2.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL62083	—	IC50	=	2000000.0	nM	2.70