Assay Detail
Binding
CHEMBL958743
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Inhibition of FLAP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Arachidonate 5-lipoxygenase-activating protein (CHEMBL4550) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.97 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29097 | — | — | 1 | 7.58 |
| CHEMBL112 | ACETAMINOPHEN | 4.0 | 1 | 4.36 |
| CHEMBL182032 | — | — | 1 | - |
| CHEMBL180650 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29097 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL112 | ACETAMINOPHEN | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL182032 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL180650 | — | IC50 | > | 1000.0 | nM | - |