Assay Detail
Functional
CHEMBL958749
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Inhibition of PGE2 synthesis in human A549 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.94 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180650 | — | — | 1 | 6.52 |
| CHEMBL412099 | — | — | 1 | 6.38 |
| CHEMBL182032 | — | — | 1 | 6.30 |
| CHEMBL487103 | — | — | 1 | 5.70 |
| CHEMBL509791 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180650 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL412099 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL182032 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL487103 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL509791 | — | IC50 | = | 16000.0 | nM | 4.80 |