Assay Detail
Functional
CHEMBL958764
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Antiproliferative activity against human U2OS cells after 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.63 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 8.49 |
| CHEMBL501696 | APRATOXIN A | — | 1 | 8.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.62 |
| CHEMBL506311 | APRATOXIN E | — | 1 | 7.23 |
| CHEMBL525420 | E-DEHYDROAPRATOXIN A | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL501696 | APRATOXIN A | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL506311 | APRATOXIN E | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL525420 | E-DEHYDROAPRATOXIN A | IC50 | = | 160.0 | nM | 6.80 |