Assay Detail
Binding
CHEMBL958804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant B-Raf-V600E mutant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.37 | 4.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488646 | — | — | 1 | 4.42 |
| CHEMBL201511 | MALEIMIDE | — | 1 | 4.40 |
| CHEMBL509435 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488646 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL201511 | MALEIMIDE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL509435 | — | IC50 | = | 50000.0 | nM | 4.30 |