Assay Detail
Binding
CHEMBL959289
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Inhibition of Caenorhabditis elegans CAH-4b by stopped flow CO2 hydration assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Caenorhabditis elegans |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.35 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455271 | — | — | 1 | 8.02 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.46 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.40 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.38 |
| CHEMBL262628 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455271 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL262628 | — | Ki | = | 339.0 | nM | 6.47 |