Assay Detail
Functional
CHEMBL959320
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Antiproliferative activity against human QG56 cells after 3 days
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | QG-56 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new camptothecin analogs with improved antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.74 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492573 | — | — | 1 | 9.80 |
| CHEMBL524170 | — | — | 1 | 9.60 |
| CHEMBL492975 | — | — | 1 | 9.24 |
| CHEMBL492381 | — | — | 1 | 8.92 |
| CHEMBL493368 | — | — | 1 | 8.92 |
| CHEMBL523188 | — | — | 1 | 8.74 |
| CHEMBL493935 | — | — | 1 | 8.74 |
| CHEMBL493949 | — | — | 1 | 8.68 |
| CHEMBL493342 | — | — | 1 | 8.64 |
| CHEMBL523182 | — | — | 1 | 8.64 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.55 |
| CHEMBL492974 | — | — | 1 | 8.07 |
| CHEMBL493146 | — | — | 1 | 8.03 |
| CHEMBL493367 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492573 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL524170 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL492975 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL492381 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL493368 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL523188 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL493935 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL493949 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL493342 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL523182 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL492974 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL493146 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL493367 | — | IC50 | = | 18.0 | nM | 7.75 |