Assay Detail
Functional
CHEMBL959321
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Antiproliferative activity against human NCI-H460 cells after 3 days
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new camptothecin analogs with improved antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.92 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492573 | — | — | 1 | 10.10 |
| CHEMBL524170 | — | — | 1 | 9.96 |
| CHEMBL492381 | — | — | 1 | 9.42 |
| CHEMBL523188 | — | — | 1 | 9.28 |
| CHEMBL493935 | — | — | 1 | 9.18 |
| CHEMBL492975 | — | — | 1 | 9.14 |
| CHEMBL493949 | — | — | 1 | 9.04 |
| CHEMBL493368 | — | — | 1 | 9.00 |
| CHEMBL523182 | — | — | 1 | 8.80 |
| CHEMBL493342 | — | — | 1 | 8.64 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.48 |
| CHEMBL493146 | — | — | 1 | 8.14 |
| CHEMBL492974 | — | — | 1 | 8.09 |
| CHEMBL493367 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492573 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL524170 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL492381 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL523188 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL493935 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL492975 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL493949 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL493368 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL523182 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL493342 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL493146 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL492974 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL493367 | — | IC50 | = | 26.0 | nM | 7.58 |