Assay Detail
Binding
CHEMBL959525
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Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania major |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinuclidine derivatives as potential antiparasitics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 6.84 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279261 | — | — | 1 | 7.89 |
| CHEMBL258717 | — | — | 1 | 7.89 |
| CHEMBL258503 | — | — | 1 | 7.48 |
| CHEMBL453439 | — | — | 1 | 7.00 |
| CHEMBL259665 | — | — | 1 | 6.75 |
| CHEMBL478981 | — | — | 1 | 6.31 |
| CHEMBL478348 | — | — | 1 | 6.01 |
| CHEMBL443678 | — | — | 1 | 5.37 |
| CHEMBL504277 | — | — | 1 | - |
| CHEMBL477079 | — | — | 1 | - |
| CHEMBL478912 | — | — | 1 | - |
| CHEMBL2094001 | — | — | 1 | - |
| CHEMBL478359 | — | — | 1 | - |
| CHEMBL517057 | — | — | 1 | - |
| CHEMBL478358 | — | — | 1 | - |
| CHEMBL506578 | — | — | 1 | - |
| CHEMBL517203 | — | — | 1 | - |
| CHEMBL477506 | — | — | 1 | - |
| CHEMBL515183 | — | — | 1 | - |
| CHEMBL478913 | — | — | 1 | - |
| CHEMBL99679 | — | — | 1 | - |
| CHEMBL506873 | — | — | 1 | - |
| CHEMBL479189 | — | — | 1 | - |
| CHEMBL518134 | — | — | 1 | - |
| CHEMBL516895 | — | — | 1 | - |
| CHEMBL478340 | — | — | 1 | - |
| CHEMBL109405 | — | — | 1 | - |
| CHEMBL344327 | — | — | 1 | - |
| CHEMBL516436 | — | — | 1 | - |
| CHEMBL479223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279261 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL258717 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL258503 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL453439 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL259665 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL478981 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL478348 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL443678 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL478532 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL477079 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478533 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL517050 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL477322 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478112 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL477492 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478723 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478724 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL477326 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478530 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL517819 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL391926 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL477305 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL442578 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478339 | — | IC50 | - | — | - | |
| CHEMBL479211 | — | IC50 | - | — | - | |
| CHEMBL479212 | — | IC50 | - | — | - | |
| CHEMBL518600 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478347 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478531 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478913 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL479223 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL516436 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL344327 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL109405 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478340 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL516895 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL518134 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL479189 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL506873 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL99679 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL515183 | — | IC50 | - | — | - | |
| CHEMBL504277 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478912 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2094001 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478359 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL517057 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL478358 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL506578 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL517203 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL477506 | — | IC50 | > | 1000.0 | nM | - |