Assay Detail
Functional
CHEMBL959536
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani MHOM/ET/67/L82 axenic amastigotes after 72 hrs by resazurin assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinuclidine derivatives as potential antiparasitics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 4.91 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.47 |
| CHEMBL259665 | — | — | 1 | 6.00 |
| CHEMBL479189 | — | — | 1 | 5.96 |
| CHEMBL453439 | — | — | 1 | 5.96 |
| CHEMBL344327 | — | — | 1 | 5.92 |
| CHEMBL478981 | — | — | 1 | 5.85 |
| CHEMBL478339 | — | — | 1 | 5.50 |
| CHEMBL515183 | — | — | 1 | 5.34 |
| CHEMBL479211 | — | — | 1 | 5.33 |
| CHEMBL516436 | — | — | 1 | 5.16 |
| CHEMBL477326 | — | — | 1 | 5.13 |
| CHEMBL478724 | — | — | 1 | 5.10 |
| CHEMBL445817 | — | — | 1 | 5.04 |
| CHEMBL478723 | — | — | 1 | 4.99 |
| CHEMBL479212 | — | — | 1 | 4.98 |
| CHEMBL478350 | — | — | 1 | 4.97 |
| CHEMBL478349 | — | — | 1 | 4.94 |
| CHEMBL478533 | — | — | 1 | 4.92 |
| CHEMBL516895 | — | — | 1 | 4.91 |
| CHEMBL505301 | — | — | 1 | 4.90 |
| CHEMBL477079 | — | — | 1 | 4.84 |
| CHEMBL478530 | — | — | 1 | 4.79 |
| CHEMBL478531 | — | — | 1 | 4.76 |
| CHEMBL478348 | — | — | 1 | 4.76 |
| CHEMBL478532 | — | — | 1 | 4.73 |
| CHEMBL518600 | — | — | 1 | 4.72 |
| CHEMBL442578 | — | — | 1 | 4.70 |
| CHEMBL517050 | — | — | 1 | 4.65 |
| CHEMBL443678 | — | — | 1 | 4.54 |
| CHEMBL478347 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125 | MILTEFOSINE | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL259665 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL453439 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL479189 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL344327 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL478981 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL478339 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL515183 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL479211 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL516436 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL477326 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL478724 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL445817 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL478723 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL479212 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL478350 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL478349 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL478533 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL516895 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL505301 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL477079 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL478530 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL478531 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL478348 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL478532 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL518600 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL442578 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL517050 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL443678 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL478347 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL518134 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL517819 | — | IC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL2094001 | — | IC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL477322 | — | IC50 | = | 40300.0 | nM | 4.39 |
| CHEMBL506578 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL478340 | — | IC50 | = | 72400.0 | nM | 4.14 |
| CHEMBL478912 | — | IC50 | = | 77700.0 | nM | 4.11 |
| CHEMBL478112 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL109405 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL504277 | — | IC50 | = | 82100.0 | nM | 4.09 |
| CHEMBL517057 | — | IC50 | = | 88200.0 | nM | 4.05 |
| CHEMBL506873 | — | IC50 | > | 119000.0 | nM | - |
| CHEMBL99679 | — | IC50 | > | 108000.0 | nM | - |
| CHEMBL478913 | — | IC50 | > | 149000.0 | nM | - |
| CHEMBL477492 | — | IC50 | > | 96000.0 | nM | - |
| CHEMBL477305 | — | IC50 | > | 124000.0 | nM | - |
| CHEMBL479223 | — | IC50 | > | 111000.0 | nM | - |
| CHEMBL478359 | — | IC50 | > | 132000.0 | nM | - |
| CHEMBL477327 | — | IC50 | > | 92000.0 | nM | - |
| CHEMBL478358 | — | IC50 | > | 151000.0 | nM | - |