Assay Detail
Functional
CHEMBL959732
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Antiproliferative activity against human MDA-MB-435 cells after 72 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New C5-alkylated indolobenzazepinones acting as inhibitors of tubulin polymerization: cytotoxic and antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.14 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.40 |
| CHEMBL529447 | — | — | 1 | 7.16 |
| CHEMBL486504 | N-ACETYLCOLCHINOL | -1.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL529447 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL486504 | N-ACETYLCOLCHINOL | IC50 | = | 140.0 | nM | 6.85 |