Assay Detail
Binding
CHEMBL959753
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Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in CHOK1 cell membrane
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation of piperazine derivatives as 5-HT7 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.63 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495212 | — | — | 1 | 7.72 |
| CHEMBL493816 | — | — | 1 | 7.13 |
| CHEMBL497749 | — | — | 1 | 7.07 |
| CHEMBL495678 | — | — | 1 | 7.02 |
| CHEMBL493625 | — | — | 1 | 6.45 |
| CHEMBL495250 | — | — | 1 | 5.74 |
| CHEMBL427518 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495212 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL493816 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL497749 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL495678 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL493625 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL495250 | — | IC50 | = | 1824.0 | nM | 5.74 |
| CHEMBL427518 | — | IC50 | = | 5168.0 | nM | 5.29 |