Assay Detail
Binding
CHEMBL959754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]mesulergine from human recombinant 5HT2C receptor expressed in CHOK1 cell membrane
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation of piperazine derivatives as 5-HT7 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.25 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493625 | — | — | 1 | 7.24 |
| CHEMBL495678 | — | — | 1 | 7.04 |
| CHEMBL495212 | — | — | 1 | 6.67 |
| CHEMBL497749 | — | — | 1 | 6.62 |
| CHEMBL495250 | — | — | 1 | 5.87 |
| CHEMBL493816 | — | — | 1 | 5.31 |
| CHEMBL427518 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493625 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL495678 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL495212 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL497749 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL495250 | — | IC50 | = | 1349.0 | nM | 5.87 |
| CHEMBL493816 | — | IC50 | = | 4886.0 | nM | 5.31 |
| CHEMBL427518 | — | IC50 | = | 9665.0 | nM | 5.01 |