Assay Detail
Binding
CHEMBL959755
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Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation of piperazine derivatives as 5-HT7 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.62 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495212 | — | — | 1 | 6.12 |
| CHEMBL495678 | — | — | 1 | 5.71 |
| CHEMBL497749 | — | — | 1 | 5.58 |
| CHEMBL493625 | — | — | 1 | 5.55 |
| CHEMBL495250 | — | — | 1 | 5.16 |
| CHEMBL493816 | — | — | 1 | - |
| CHEMBL427518 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495212 | — | IC50 | = | 768.0 | nM | 6.12 |
| CHEMBL495678 | — | IC50 | = | 1956.0 | nM | 5.71 |
| CHEMBL497749 | — | IC50 | = | 2634.0 | nM | 5.58 |
| CHEMBL493625 | — | IC50 | = | 2839.0 | nM | 5.55 |
| CHEMBL495250 | — | IC50 | = | 6925.0 | nM | 5.16 |
| CHEMBL493816 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL427518 | — | IC50 | > | 10000.0 | nM | - |