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Assay Detail

CHEMBL959862

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human integrin alpha-4-beta-1-mediated MOLT4 cell adhesion to biotin-conjugated CS-1 peptide
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type MOLT-4
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Integrin alpha-4/beta-1 (CHEMBL1907599)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin.
Carpenter RD, Andrei M, Aina OH, Lau EY, Lightstone FC, Liu R, Lam KS, Kurth MJ.
J Med Chem (2009) 52 : 14 -19
PubMed 19072684 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.81 10.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL447509 1 10.43
CHEMBL505769 1 10.28
CHEMBL447354 1 9.52
CHEMBL454993 1 8.74
CHEMBL505729 1 8.36
CHEMBL453921 1 7.52
CHEMBL499771 1 6.46
CHEMBL453414 1 6.42
CHEMBL455281 1 6.31
CHEMBL448236 1 5.97
CHEMBL510020 1 5.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL447509 IC50 = 0.037 nM 10.43
CHEMBL505769 IC50 = 0.0525 nM 10.28
CHEMBL447354 IC50 = 0.305 nM 9.52
CHEMBL454993 IC50 = 1.8 nM 8.74
CHEMBL505729 IC50 = 4.41 nM 8.36
CHEMBL453921 IC50 = 30.0 nM 7.52
CHEMBL499771 IC50 = 346.5 nM 6.46
CHEMBL453414 IC50 = 378.5 nM 6.42
CHEMBL455281 IC50 = 490.0 nM 6.31
CHEMBL448236 IC50 = 1070.0 nM 5.97
CHEMBL510020 IC50 = 1150.0 nM 5.94