Assay Detail
Functional
CHEMBL959878
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Antiviral activity against HCV in ET cells assessed as activity of luciferase reporter by subgenomic RNA replicon assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | ET |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.38 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73809 | — | — | 1 | 6.82 |
| CHEMBL612108 | — | — | 1 | 5.75 |
| CHEMBL612104 | — | — | 1 | 5.68 |
| CHEMBL523572 | 7-DEAZANEPLANOCIN A | — | 1 | 5.60 |
| CHEMBL612105 | — | — | 1 | 4.87 |
| CHEMBL609678 | — | — | 1 | 4.83 |
| CHEMBL612103 | — | — | 1 | 4.78 |
| CHEMBL612107 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73809 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL612108 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL612104 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL523572 | 7-DEAZANEPLANOCIN A | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL612105 | — | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL609678 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL612103 | — | EC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL612107 | — | EC50 | = | 20100.0 | nM | 4.70 |