Assay Detail

CHEMBL959906

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Intrinsic activity at 5HT1A receptor in Duncan Hartley guinea pig ileum

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Cavia porcellus
Tissue	Ileum
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.

Butini S, Gemma S, Campiani G, Franceschini S, Trotta F, Borriello M, Ceres N, Ros S, Coccone SS, Bernetti M, De Angelis M, Brindisi M, Nacci V, Fiorini I, Novellino E, Cagnotto A, Mennini T, Sandager-Nielsen K, Andreasen JT, Scheel-Kruger J, Mikkelsen JD, Fattorusso C.
J Med Chem (2009) 52 : 151 -169
PubMed 19072656 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.75	6.75

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL496739	—	—	1	6.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL496739	—	IC50	=	180.0	nM	6.75