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Assay Detail

CHEMBL960029

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H460
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-H460 (CHEMBL396)
Type CELL-LINE
Organism Homo sapiens

Publication

N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.
Giannini G, Marzi M, Pezzi R, Brunetti T, Battistuzzi G, Marzo MD, Cabri W, Vesci L, Pisano C.
Bioorg Med Chem Lett (2009) 19 : 2346 -2349
PubMed 19285395 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.41 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL505806 1 5.80
CHEMBL471041 1 5.80
CHEMBL471043 1 5.77
CHEMBL471042 1 5.58
CHEMBL472631 1 5.54
CHEMBL484924 1 5.50
CHEMBL470603 1 5.29
CHEMBL464110 1 5.20
CHEMBL470414 1 5.18
CHEMBL470843 1 5.16
CHEMBL470412 1 5.11
CHEMBL513045 1 5.00
CHEMBL469991 1 -
CHEMBL470206 1 -
CHEMBL470413 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL505806 IC50 = 1600.0 nM 5.80
CHEMBL471041 IC50 = 1600.0 nM 5.80
CHEMBL471043 IC50 = 1700.0 nM 5.77
CHEMBL471042 IC50 = 2600.0 nM 5.58
CHEMBL472631 IC50 = 2900.0 nM 5.54
CHEMBL484924 IC50 = 3200.0 nM 5.50
CHEMBL470603 IC50 = 5100.0 nM 5.29
CHEMBL464110 IC50 = 6300.0 nM 5.20
CHEMBL470414 IC50 = 6600.0 nM 5.18
CHEMBL470843 IC50 = 7000.0 nM 5.16
CHEMBL470412 IC50 = 7700.0 nM 5.11
CHEMBL513045 IC50 = 9900.0 nM 5.00
CHEMBL469991 IC50 > 20000.0 nM -
CHEMBL470206 IC50 > 20000.0 nM -
CHEMBL470413 IC50 > 20000.0 nM -