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Assay Detail

CHEMBL960144

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of ErbB2 by virtual HTS assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping.
Tasler S, Müller O, Wieber T, Herz T, Krauss R, Totzke F, Kubbutat MH, Schächtele C.
Bioorg Med Chem Lett (2009) 19 : 1349 -1356
PubMed 19211246 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.22 7.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL301018 1 7.62
CHEMBL464210 1 5.96
CHEMBL462162 1 5.80
CHEMBL518803 1 5.51
CHEMBL474346 1 -
CHEMBL514929 1 -
CHEMBL472946 1 -
CHEMBL475352 1 -
CHEMBL475351 1 -
CHEMBL462338 1 -
CHEMBL461110 1 -
CHEMBL459886 1 -
CHEMBL462160 1 -
CHEMBL474347 1 -
CHEMBL461991 1 -
CHEMBL464014 1 -
CHEMBL462161 1 -
CHEMBL461109 1 -
CHEMBL515598 1 -
CHEMBL512933 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL301018 IC50 = 24.0 nM 7.62
CHEMBL464210 IC50 = 1100.0 nM 5.96
CHEMBL462162 IC50 = 1600.0 nM 5.80
CHEMBL518803 IC50 = 3100.0 nM 5.51
CHEMBL474346 IC50 > 10000.0 nM -
CHEMBL514929 IC50 > 10000.0 nM -
CHEMBL472946 IC50 > 10000.0 nM -
CHEMBL475352 IC50 > 10000.0 nM -
CHEMBL475351 IC50 > 10000.0 nM -
CHEMBL462338 IC50 > 10000.0 nM -
CHEMBL461110 IC50 > 10000.0 nM -
CHEMBL459886 IC50 > 10000.0 nM -
CHEMBL462160 IC50 > 10000.0 nM -
CHEMBL474347 IC50 > 10000.0 nM -
CHEMBL461991 IC50 > 10000.0 nM -
CHEMBL464014 IC50 > 10000.0 nM -
CHEMBL462161 IC50 - -
CHEMBL461109 IC50 - -
CHEMBL515598 IC50 - -
CHEMBL512933 IC50 > 10000.0 nM -