Assay Detail
Binding
CHEMBL960159
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Inhibition of human recombinant caspase 6 assessed as accumulation of fluorogenic product by fluorometric assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.40 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478081 | — | — | 1 | 8.10 |
| CHEMBL523131 | — | — | 1 | 6.82 |
| CHEMBL516251 | — | — | 1 | 6.81 |
| CHEMBL490850 | — | — | 1 | 6.73 |
| CHEMBL476023 | — | — | 1 | 6.71 |
| CHEMBL490851 | — | — | 1 | 6.64 |
| CHEMBL477047 | — | — | 1 | 6.62 |
| CHEMBL510809 | — | — | 1 | 6.55 |
| CHEMBL519148 | — | — | 1 | 6.49 |
| CHEMBL477659 | — | — | 1 | 6.45 |
| CHEMBL492060 | — | — | 1 | 6.37 |
| CHEMBL492061 | — | — | 1 | 6.34 |
| CHEMBL478694 | — | — | 1 | 6.33 |
| CHEMBL521801 | — | — | 1 | 6.26 |
| CHEMBL492059 | — | — | 1 | 6.25 |
| CHEMBL521972 | — | — | 1 | 6.23 |
| CHEMBL226779 | — | — | 1 | 6.04 |
| CHEMBL476022 | — | — | 1 | 5.01 |
| CHEMBL482841 | — | — | 1 | 4.89 |
| CHEMBL482634 | — | — | 1 | - |
| CHEMBL484273 | — | — | 1 | - |
| CHEMBL439753 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478081 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL523131 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL516251 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL490850 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL476023 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL490851 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL477047 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL510809 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL519148 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL477659 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL492060 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL492061 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL478694 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL521801 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL492059 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL521972 | — | IC50 | = | 591.7 | nM | 6.23 |
| CHEMBL226779 | — | IC50 | = | 918.0 | nM | 6.04 |
| CHEMBL476022 | — | IC50 | = | 9833.0 | nM | 5.01 |
| CHEMBL482841 | — | IC50 | = | 12833.0 | nM | 4.89 |
| CHEMBL482634 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL484273 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL439753 | — | IC50 | > | 5000.0 | nM | - |