Assay Detail
Binding
CHEMBL960160
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Inhibition of human recombinant caspase 7 assessed as accumulation of fluorogenic product by fluorometric assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.07 | 8.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417149 | — | — | 1 | 8.53 |
| CHEMBL476022 | — | — | 1 | 6.88 |
| CHEMBL516251 | — | — | 1 | 6.61 |
| CHEMBL510809 | — | — | 1 | 6.47 |
| CHEMBL477659 | — | — | 1 | 6.35 |
| CHEMBL476023 | — | — | 1 | 6.33 |
| CHEMBL478694 | — | — | 1 | 6.33 |
| CHEMBL477047 | — | — | 1 | 6.23 |
| CHEMBL519148 | — | — | 1 | 6.06 |
| CHEMBL521801 | — | — | 1 | 5.94 |
| CHEMBL482841 | — | — | 1 | 5.83 |
| CHEMBL523131 | — | — | 1 | 5.79 |
| CHEMBL490850 | — | — | 1 | 5.72 |
| CHEMBL482634 | — | — | 1 | 5.65 |
| CHEMBL492059 | — | — | 1 | 5.47 |
| CHEMBL492061 | — | — | 1 | 5.39 |
| CHEMBL492060 | — | — | 1 | 5.35 |
| CHEMBL490851 | — | — | 1 | 5.29 |
| CHEMBL521972 | — | — | 1 | 5.10 |
| CHEMBL484273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417149 | — | IC50 | = | 2.95 | nM | 8.53 |
| CHEMBL476022 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL516251 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL510809 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL477659 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL476023 | — | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL478694 | — | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL477047 | — | IC50 | = | 587.0 | nM | 6.23 |
| CHEMBL519148 | — | IC50 | = | 878.0 | nM | 6.06 |
| CHEMBL521801 | — | IC50 | = | 1147.0 | nM | 5.94 |
| CHEMBL482841 | — | IC50 | = | 1483.0 | nM | 5.83 |
| CHEMBL523131 | — | IC50 | = | 1625.0 | nM | 5.79 |
| CHEMBL490850 | — | IC50 | = | 1893.0 | nM | 5.72 |
| CHEMBL482634 | — | IC50 | = | 2233.0 | nM | 5.65 |
| CHEMBL492059 | — | IC50 | = | 3416.0 | nM | 5.47 |
| CHEMBL492061 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL492060 | — | IC50 | = | 4467.0 | nM | 5.35 |
| CHEMBL490851 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL521972 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL484273 | — | IC50 | > | 20000.0 | nM | - |