Assay Detail
Binding
CHEMBL960183
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Inhibition of Varicella Zoster virus thymidine kinase-mediated [3H]thymidine phosphorylation
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.45 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523439 | — | — | 1 | 6.51 |
| CHEMBL489047 | — | — | 1 | 5.72 |
| CHEMBL484070 | — | — | 1 | 5.64 |
| CHEMBL485095 | — | — | 1 | 5.62 |
| CHEMBL489647 | — | — | 1 | 5.58 |
| CHEMBL489048 | — | — | 1 | 5.42 |
| CHEMBL344738 | CF1743 | — | 1 | 5.39 |
| CHEMBL146212 | — | — | 1 | 5.33 |
| CHEMBL522752 | — | — | 1 | 4.64 |
| CHEMBL147162 | — | — | 1 | 4.60 |
| CHEMBL444555 | — | — | 1 | - |
| CHEMBL521178 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523439 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL489047 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL484070 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL485095 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL489647 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL489048 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL344738 | CF1743 | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL146212 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL522752 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL147162 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL444555 | — | IC50 | = | 119000.0 | nM | - |
| CHEMBL521178 | — | IC50 | = | 397000.0 | nM | - |