Assay Detail
Binding
CHEMBL960209
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Inhibition of Sprague-Dawley rat mitochondrial aldehyde dehydrogenase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldehyde dehydrogenase, mitochondrial (CHEMBL2812) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Elgonica-Dimers A and B, Two Potent Alcohol Metabolism Inhibitory Constituents of Aloe arborescens
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.94 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449188 | — | — | 1 | 6.44 |
| CHEMBL494494 | — | — | 1 | 6.14 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449188 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL494494 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL673 | PARGYLINE | IC50 | = | 5600.0 | nM | 5.25 |