Assay Detail
Binding
CHEMBL960363
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Inhibition of HDAC from human HeLa cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.24 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485514 | — | — | 1 | 8.30 |
| CHEMBL490261 | — | — | 1 | 8.15 |
| CHEMBL484489 | — | — | 1 | 8.10 |
| CHEMBL484073 | — | — | 1 | 8.05 |
| CHEMBL490255 | — | — | 1 | 7.70 |
| CHEMBL454719 | — | — | 1 | 7.68 |
| CHEMBL490018 | — | — | 1 | 7.64 |
| CHEMBL483260 | — | — | 1 | 7.60 |
| CHEMBL490254 | — | — | 1 | 7.55 |
| CHEMBL448955 | — | — | 1 | 7.54 |
| CHEMBL453755 | — | — | 1 | 7.50 |
| CHEMBL501518 | — | — | 1 | 7.44 |
| CHEMBL143327 | — | — | 1 | 7.42 |
| CHEMBL451583 | — | — | 1 | 7.34 |
| CHEMBL504898 | — | — | 1 | 7.21 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.06 |
| CHEMBL521766 | — | — | 1 | 7.00 |
| CHEMBL46942 | — | — | 1 | 6.96 |
| CHEMBL490260 | — | — | 1 | 6.85 |
| CHEMBL485513 | — | — | 1 | 6.70 |
| CHEMBL143849 | — | — | 1 | 6.62 |
| CHEMBL519210 | — | — | 1 | 6.47 |
| CHEMBL484487 | — | — | 1 | 6.20 |
| CHEMBL490259 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485514 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL490261 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL484489 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL484073 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL490255 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL454719 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL490018 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL483260 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL490254 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL448955 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL453755 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL501518 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL143327 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL451583 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL504898 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL521766 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL46942 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL490260 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL485513 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL143849 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL519210 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL484487 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL490259 | — | IC50 | = | 22850.0 | nM | 4.64 |