Assay Detail
Binding
CHEMBL960365
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Inhibition of human recombinant HDAC2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.30 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485514 | — | — | 1 | 9.10 |
| CHEMBL484073 | — | — | 1 | 8.60 |
| CHEMBL484489 | — | — | 1 | 8.52 |
| CHEMBL490018 | — | — | 1 | 8.51 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485514 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL484073 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL484489 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL490018 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 163.6 | nM | 6.79 |