Assay Detail
Binding
CHEMBL960371
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Inhibition of human recombinant HDAC8
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.82 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485514 | — | — | 1 | 6.11 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.86 |
| CHEMBL484489 | — | — | 1 | 5.79 |
| CHEMBL484073 | — | — | 1 | 5.69 |
| CHEMBL490018 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485514 | — | IC50 | = | 779.0 | nM | 6.11 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1374.7 | nM | 5.86 |
| CHEMBL484489 | — | IC50 | = | 1619.7 | nM | 5.79 |
| CHEMBL484073 | — | IC50 | = | 2028.3 | nM | 5.69 |
| CHEMBL490018 | — | IC50 | = | 2116.3 | nM | 5.67 |