Assay Detail
Functional
CHEMBL960373
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Antiproliferative activity against human HeLa cells after 4 hrs by WST-1 assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.95 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490255 | — | — | 1 | 6.40 |
| CHEMBL454719 | — | — | 1 | 5.96 |
| CHEMBL485514 | — | — | 1 | 5.77 |
| CHEMBL143327 | — | — | 1 | 5.58 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.51 |
| CHEMBL490254 | — | — | 1 | 5.44 |
| CHEMBL46942 | — | — | 1 | 5.39 |
| CHEMBL490018 | — | — | 1 | 5.32 |
| CHEMBL448955 | — | — | 1 | 5.29 |
| CHEMBL453755 | — | — | 1 | 5.26 |
| CHEMBL484489 | — | — | 1 | 5.20 |
| CHEMBL143849 | — | — | 1 | 5.20 |
| CHEMBL485513 | — | — | 1 | 5.07 |
| CHEMBL451583 | — | — | 1 | 5.02 |
| CHEMBL519210 | — | — | 1 | 5.00 |
| CHEMBL504898 | — | — | 1 | 4.97 |
| CHEMBL484073 | — | — | 1 | 4.91 |
| CHEMBL483477 | — | — | 1 | 4.88 |
| CHEMBL490261 | — | — | 1 | 4.74 |
| CHEMBL484487 | — | — | 1 | 4.69 |
| CHEMBL483260 | — | — | 1 | 4.68 |
| CHEMBL490057 | — | — | 1 | 4.62 |
| CHEMBL489436 | — | — | 1 | 4.61 |
| CHEMBL490260 | — | — | 1 | 4.55 |
| CHEMBL484695 | — | — | 1 | 4.45 |
| CHEMBL501518 | — | — | 1 | 4.42 |
| CHEMBL483476 | — | — | 1 | 4.36 |
| CHEMBL521766 | — | — | 1 | 4.33 |
| CHEMBL487922 | — | — | 1 | 4.28 |
| CHEMBL484488 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490255 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL454719 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL485514 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL143327 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL490254 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL46942 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL490018 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL448955 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL453755 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL484489 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL143849 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL485513 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL451583 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL519210 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL504898 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL484073 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL483477 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL490261 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL484487 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL483260 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL490057 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL489436 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL490260 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL484695 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL501518 | — | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL483476 | — | IC50 | = | 44200.0 | nM | 4.36 |
| CHEMBL521766 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL487922 | — | IC50 | = | 52700.0 | nM | 4.28 |
| CHEMBL484488 | — | IC50 | = | 52700.0 | nM | 4.28 |
| CHEMBL482435 | — | IC50 | = | 70800.0 | nM | 4.15 |
| CHEMBL444257 | — | IC50 | = | 74800.0 | nM | 4.13 |
| CHEMBL490259 | — | IC50 | = | 113500.0 | nM | - |