Assay Detail
Binding
CHEMBL960615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylation by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.30 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453649 | — | — | 1 | 5.40 |
| CHEMBL509485 | — | — | 1 | 5.35 |
| CHEMBL452340 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453649 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL509485 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL452340 | — | IC50 | = | 6900.0 | nM | 5.16 |