Assay Detail
Functional
CHEMBL960665
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Antiviral activity against HCV in human Huh7 cells assessed as reduction of viral level after 5 days by RNA subgenomic replicon assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.76 | 6.05 |
| EC90 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523572 | 7-DEAZANEPLANOCIN A | — | 2 | 6.05 |
| CHEMBL497390 | — | — | 2 | 5.77 |
| CHEMBL438605 | — | — | 2 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523572 | 7-DEAZANEPLANOCIN A | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL497390 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL438605 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL523572 | 7-DEAZANEPLANOCIN A | EC90 | = | 8.2 | uM | - |
| CHEMBL438605 | — | EC90 | = | 11.0 | uM | - |
| CHEMBL497390 | — | EC90 | = | 5.3 | uM | - |