Assay Detail
Binding
CHEMBL960871
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Inhibition of human VEGFR2
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.01 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615278 | — | — | 1 | 6.10 |
| CHEMBL1794070 | GSK-579289A | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615278 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1794070 | GSK-579289A | IC50 | = | 1200.0 | nM | 5.92 |