Assay Detail
Functional
CHEMBL960918
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Inhibition of LPS-induced TNFalpha production in human PBMC preincubated for 30 mins before LPS challenge measured afterr 6 hrs by ELISA
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel tricyclic inhibitors of IkappaB kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.23 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522014 | — | — | 1 | 7.09 |
| CHEMBL493974 | — | — | 1 | 6.80 |
| CHEMBL494162 | — | — | 1 | 6.77 |
| CHEMBL521643 | — | — | 1 | 6.51 |
| CHEMBL454973 | — | — | 1 | 6.46 |
| CHEMBL493940 | — | — | 1 | 6.41 |
| CHEMBL522011 | — | — | 1 | 6.36 |
| CHEMBL522318 | — | — | 1 | 6.35 |
| CHEMBL493745 | — | — | 1 | 6.33 |
| CHEMBL505943 | — | — | 1 | 6.24 |
| CHEMBL492755 | — | — | 1 | 6.20 |
| CHEMBL492332 | — | — | 1 | 6.18 |
| CHEMBL492331 | — | — | 1 | 6.07 |
| CHEMBL504727 | — | — | 1 | 6.01 |
| CHEMBL492527 | — | — | 1 | 5.77 |
| CHEMBL454470 | — | — | 1 | 5.58 |
| CHEMBL447603 | — | — | 1 | 5.48 |
| CHEMBL523002 | — | — | 1 | 5.46 |
| CHEMBL492754 | — | — | 1 | - |
| CHEMBL494154 | — | — | 1 | - |
| CHEMBL494153 | — | — | 1 | - |
| CHEMBL506895 | — | — | 1 | - |
| CHEMBL522171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522014 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL493974 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL494162 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL521643 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL454973 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL493940 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL522011 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL522318 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL493745 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL505943 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL492755 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL492332 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL492331 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL504727 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL492527 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL454470 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL447603 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL523002 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL492754 | — | IC50 | - | — | - | |
| CHEMBL494154 | — | IC50 | - | — | - | |
| CHEMBL494153 | — | IC50 | - | — | - | |
| CHEMBL506895 | — | IC50 | - | — | - | |
| CHEMBL522171 | — | IC50 | - | — | - |