Assay Detail
Binding
CHEMBL960947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.11 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489326 | EXELIXIS | — | 1 | 8.15 |
| CHEMBL404881 | — | — | 1 | 7.50 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 6.73 |
| CHEMBL450786 | PHA-665752 | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489326 | EXELIXIS | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL404881 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL535 | SUNITINIB | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 863.0 | nM | 6.06 |