Assay Detail
Binding
CHEMBL960972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]hMCP1 from human CCR2 receptor expressed in CHO cells
38
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.41 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494191 | — | — | 4 | 8.92 |
| CHEMBL522688 | — | — | 4 | 8.52 |
| CHEMBL495368 | — | — | 1 | 8.34 |
| CHEMBL492569 | — | — | 1 | 8.26 |
| CHEMBL492564 | — | — | 3 | 8.22 |
| CHEMBL495151 | — | — | 1 | 8.15 |
| CHEMBL494540 | — | — | 1 | 8.11 |
| CHEMBL494580 | — | — | 2 | 8.07 |
| CHEMBL521697 | — | — | 1 | 7.66 |
| CHEMBL495149 | — | — | 1 | 7.55 |
| CHEMBL41275 | — | — | 1 | 7.55 |
| CHEMBL523054 | — | — | 1 | 7.52 |
| CHEMBL495165 | — | — | 1 | 7.44 |
| CHEMBL494542 | — | — | 1 | 7.29 |
| CHEMBL494770 | — | — | 1 | 7.25 |
| CHEMBL493780 | — | — | 1 | 7.19 |
| CHEMBL494019 | — | — | 1 | 7.11 |
| CHEMBL494591 | — | — | 1 | 7.07 |
| CHEMBL494541 | — | — | 1 | 6.91 |
| CHEMBL523857 | — | — | 1 | 6.81 |
| CHEMBL494399 | — | — | 1 | 6.76 |
| CHEMBL523696 | — | — | 1 | 6.73 |
| CHEMBL493575 | — | — | 1 | 6.71 |
| CHEMBL492376 | — | — | 1 | 6.64 |
| CHEMBL523861 | — | — | 1 | 6.62 |
| CHEMBL493779 | — | — | 1 | 6.44 |
| CHEMBL524030 | — | — | 1 | 6.38 |
| CHEMBL493843 | — | — | 1 | 6.20 |
| CHEMBL523503 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494191 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL494191 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL522688 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL522688 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL494191 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL495368 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL492569 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL522688 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL492564 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL495151 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL494540 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL494580 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL492564 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL521697 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL495149 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL41275 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL523054 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL495165 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL494191 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL494542 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL494770 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL493780 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL494019 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL494591 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL494541 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL522688 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL523857 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL494399 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL523696 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL493575 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL492376 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL523861 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL492564 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL493779 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL524030 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL494580 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL493843 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL523503 | — | IC50 | = | 765.0 | nM | 6.12 |