Assay Detail
Functional
CHEMBL960991
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human COLO205 cells after 72 hrs by luminescence-based cell viability assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615278 | — | — | 1 | 8.30 |
| CHEMBL1794070 | GSK-579289A | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615278 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1794070 | GSK-579289A | IC50 | = | 5.0 | nM | 8.30 |