Assay Detail
Binding
CHEMBL961041
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Inhibition of human cloned 5HT7 receptor by competitive binding experiment
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.17 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515472 | — | — | 1 | 7.23 |
| CHEMBL402143 | — | — | 1 | 6.94 |
| CHEMBL516088 | — | — | 1 | 6.68 |
| CHEMBL476839 | — | — | 1 | 6.30 |
| CHEMBL490632 | — | — | 1 | 6.14 |
| CHEMBL489408 | — | — | 1 | 5.54 |
| CHEMBL476838 | — | — | 1 | 5.29 |
| CHEMBL490634 | — | — | 1 | 5.21 |
| CHEMBL490633 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515472 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL402143 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL516088 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL476839 | — | Ki | = | 498.0 | nM | 6.30 |
| CHEMBL490632 | — | Ki | = | 731.0 | nM | 6.14 |
| CHEMBL489408 | — | Ki | = | 2862.0 | nM | 5.54 |
| CHEMBL476838 | — | Ki | = | 5170.0 | nM | 5.29 |
| CHEMBL490634 | — | Ki | = | 6241.0 | nM | 5.21 |
| CHEMBL490633 | — | Ki | > | 10000.0 | nM | - |