Assay Detail
Binding
CHEMBL961043
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Inhibition of human cloned dopamine D4 receptor by competitive binding experiment
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.20 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516088 | — | — | 1 | 6.76 |
| CHEMBL515472 | — | — | 1 | 6.36 |
| CHEMBL402143 | — | — | 1 | 6.26 |
| CHEMBL490632 | — | — | 1 | 6.04 |
| CHEMBL476839 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516088 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL515472 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL402143 | — | Ki | = | 544.0 | nM | 6.26 |
| CHEMBL490632 | — | Ki | = | 923.0 | nM | 6.04 |
| CHEMBL476839 | — | Ki | = | 2708.0 | nM | 5.57 |