Assay Detail

CHEMBL961155

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxicity against human KB cells

ChEMBL ↗

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Target

KB (CHEMBL398) ↗

Open DB target context

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Primary target KB

CHEMBL398

Anchored from Assay target.

Protein identity KB

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	KB
Confidence	1 — Organism
Curated By	Autocuration

Target

KB (CHEMBL398) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Ecteinascidins 770 and 786 from the Thai tunicate Ecteinascidia thurstoni.

Suwanborirux K, Charupant K, Amnuoypol S, Pummangura S, Kubo A, Saito N.
J Nat Prod (2002) 65 : 935 -937
PubMed 12088444 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	10.15	10.47

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL448144	ECTEINASCIDIN 770	—	1	10.47
CHEMBL451892	ECTEINASCIDIN 786	—	1	9.82

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL448144	ECTEINASCIDIN 770	IC50	=	0.034	nM	10.47
CHEMBL451892	ECTEINASCIDIN 786	IC50	=	0.15	nM	9.82