Assay Detail
Binding
CHEMBL961374
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Inhibition of P-glycoprotein-mediated rhodamine 123 absorption in guinea-pig ileum
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.61 | 4.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387052 | — | — | 1 | 4.83 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 4.60 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387052 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL83 | TAMOXIFEN | EC50 | = | 39400.0 | nM | 4.41 |