Assay Detail
Binding
CHEMBL961375
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Inhibition of P-glycoprotein-mediated [3H]vinblastine transport in human Caco-2 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.46 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 4.70 |
| CHEMBL387052 | — | — | 1 | 4.56 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 4.34 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL387052 | — | EC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 45500.0 | nM | 4.34 |
| CHEMBL83 | TAMOXIFEN | EC50 | = | 56500.0 | nM | 4.25 |