Assay Detail
Functional
CHEMBL961432
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Antiplasmodial activity against Plasmodium falciparum 3D7 in erythrocytes as [3H]hypoxanthine uptake
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.86 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475813 | — | — | 1 | 7.10 |
| CHEMBL475814 | — | — | 1 | 6.72 |
| CHEMBL484294 | — | — | 1 | 6.51 |
| CHEMBL484305 | — | — | 1 | 6.39 |
| CHEMBL486489 | — | — | 1 | 6.26 |
| CHEMBL503135 | — | — | 1 | 5.80 |
| CHEMBL487518 | — | — | 1 | 5.77 |
| CHEMBL451880 | — | — | 1 | 5.66 |
| CHEMBL519836 | — | — | 1 | 5.48 |
| CHEMBL449358 | — | — | 1 | 5.36 |
| CHEMBL486490 | — | — | 1 | 4.80 |
| CHEMBL486697 | — | — | 1 | 4.46 |
| CHEMBL446825 | — | — | 1 | - |
| CHEMBL487517 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475813 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL475814 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL484294 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL484305 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL486489 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL503135 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL487518 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL451880 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL519836 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL449358 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL486490 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL486697 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL446825 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL487517 | — | IC50 | > | 50000.0 | nM | - |