Assay Detail
Binding
CHEMBL961473
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Binding affinity to human PBR
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.45 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481537 | PK-11195 | — | 1 | 8.70 |
| CHEMBL517539 | — | — | 1 | 8.46 |
| CHEMBL63154 | — | — | 1 | 8.40 |
| CHEMBL286346 | RO-54864 | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481537 | PK-11195 | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL517539 | — | Kd | = | 3.5 | nM | 8.46 |
| CHEMBL63154 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL286346 | RO-54864 | Kd | = | 6.0 | nM | 8.22 |