Assay Detail
Binding
CHEMBL961580
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Inhibition of human aquaporin 4 M23 isoform expressed in Xenopus laevis oocytes
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of aquaporin 4 by antiepileptic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.33 | 6.07 |
| Imax | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 2 | 6.07 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 2 | 5.48 |
| CHEMBL741 | LAMOTRIGINE | 4.0 | 2 | 5.09 |
| CHEMBL16 | PHENYTOIN | 4.0 | 2 | 5.01 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 2 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL750 | ZONISAMIDE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL741 | LAMOTRIGINE | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL16 | PHENYTOIN | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL220492 | TOPIRAMATE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL220492 | TOPIRAMATE | Imax | = | 75.0 | % | - |
| CHEMBL750 | ZONISAMIDE | Imax | = | 48.0 | % | - |
| CHEMBL16 | PHENYTOIN | Imax | = | 60.0 | % | - |
| CHEMBL741 | LAMOTRIGINE | Imax | = | 64.0 | % | - |
| CHEMBL20 | ACETAZOLAMIDE | Imax | = | 86.0 | % | - |