Assay Detail
Binding
CHEMBL961600
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Trypanosoma cruzi recombinant cruzain by fluorescence technique
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.05 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91704 | K-777 | 2.0 | 1 | 8.40 |
| CHEMBL454688 | — | — | 1 | 5.70 |
| CHEMBL452863 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91704 | K-777 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL454688 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL452863 | — | IC50 | > | 10000.0 | nM | - |