Assay Detail
Binding
CHEMBL961602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TGH
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.65 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220125 | — | — | 1 | 7.70 |
| CHEMBL220770 | — | — | 1 | 7.70 |
| CHEMBL462423 | — | — | 1 | 7.52 |
| CHEMBL461544 | — | — | 1 | 7.22 |
| CHEMBL373606 | — | — | 1 | 6.70 |
| CHEMBL177577 | — | — | 1 | 6.22 |
| CHEMBL513787 | — | — | 1 | 6.16 |
| CHEMBL460317 | — | — | 1 | 5.60 |
| CHEMBL461541 | — | — | 1 | 5.00 |
| CHEMBL220729 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220125 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL220770 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL462423 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL461544 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL373606 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL177577 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL513787 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL460317 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL461541 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL220729 | — | IC50 | > | 100000.0 | nM | - |