Assay Detail
Functional
CHEMBL961670
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Cytotoxicity against human KB cells after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.67 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270441 | — | — | 1 | 6.52 |
| CHEMBL478687 | — | — | 1 | 5.64 |
| CHEMBL477052 | — | — | 1 | 5.35 |
| CHEMBL476423 | — | — | 1 | 5.07 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.94 |
| CHEMBL387599 | — | — | 1 | 4.53 |
| CHEMBL388544 | — | — | 1 | 4.44 |
| CHEMBL477256 | — | — | 1 | 4.24 |
| CHEMBL269929 | — | — | 1 | 4.19 |
| CHEMBL428950 | — | — | 1 | 4.18 |
| CHEMBL476631 | — | — | 1 | 4.16 |
| CHEMBL476623 | — | — | 1 | 4.07 |
| CHEMBL477049 | — | — | 1 | 4.06 |
| CHEMBL478481 | — | — | 1 | 4.01 |
| CHEMBL477061 | — | — | 1 | - |
| CHEMBL476424 | — | — | 1 | - |
| CHEMBL477053 | — | — | 1 | - |
| CHEMBL514060 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270441 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL478687 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL477052 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL476423 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL140 | CURCUMIN | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL387599 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL388544 | — | IC50 | = | 36500.0 | nM | 4.44 |
| CHEMBL477256 | — | IC50 | = | 58100.0 | nM | 4.24 |
| CHEMBL269929 | — | IC50 | = | 64600.0 | nM | 4.19 |
| CHEMBL428950 | — | IC50 | = | 65800.0 | nM | 4.18 |
| CHEMBL476631 | — | IC50 | = | 69200.0 | nM | 4.16 |
| CHEMBL476623 | — | IC50 | = | 85800.0 | nM | 4.07 |
| CHEMBL477049 | — | IC50 | = | 87200.0 | nM | 4.06 |
| CHEMBL478481 | — | IC50 | = | 98300.0 | nM | 4.01 |
| CHEMBL477061 | — | IC50 | = | 134000.0 | nM | - |
| CHEMBL476424 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL477053 | — | IC50 | < | 12600.0 | nM | - |
| CHEMBL514060 | — | IC50 | = | 225000.0 | nM | - |