Assay Detail
Functional
CHEMBL961673
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Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.79 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476424 | — | — | 1 | 6.46 |
| CHEMBL478687 | — | — | 1 | 5.28 |
| CHEMBL478689 | — | — | 1 | 5.28 |
| CHEMBL477054 | — | — | 1 | 5.06 |
| CHEMBL255963 | — | — | 1 | 4.99 |
| CHEMBL498590 | — | — | 1 | 4.92 |
| CHEMBL478481 | — | — | 1 | 4.86 |
| CHEMBL476220 | — | — | 1 | 4.82 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.82 |
| CHEMBL504452 | — | — | 1 | 4.81 |
| CHEMBL428950 | — | — | 1 | 4.66 |
| CHEMBL387599 | — | — | 1 | 4.64 |
| CHEMBL476847 | — | — | 1 | 4.61 |
| CHEMBL476601 | — | — | 1 | 4.46 |
| CHEMBL270441 | — | — | 1 | 4.36 |
| CHEMBL517667 | — | — | 1 | 4.34 |
| CHEMBL129134 | — | — | 1 | 4.31 |
| CHEMBL476218 | — | — | 1 | 4.21 |
| CHEMBL517965 | — | — | 1 | 4.11 |
| CHEMBL476628 | — | — | 1 | - |
| CHEMBL445482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476424 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL478687 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL478689 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL477054 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL255963 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL498590 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL478481 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL476220 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL140 | CURCUMIN | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL504452 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL428950 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL387599 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL476847 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL476601 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL270441 | — | IC50 | = | 43400.0 | nM | 4.36 |
| CHEMBL517667 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL129134 | — | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL476218 | — | IC50 | = | 61500.0 | nM | 4.21 |
| CHEMBL517965 | — | IC50 | = | 77600.0 | nM | 4.11 |
| CHEMBL476628 | — | IC50 | = | 117000.0 | nM | - |
| CHEMBL445482 | — | IC50 | = | 138000.0 | nM | - |