Assay Detail
Functional
CHEMBL961674
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Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.72 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476846 | — | — | 1 | 5.92 |
| CHEMBL255963 | — | — | 1 | 5.21 |
| CHEMBL478689 | — | — | 1 | 5.21 |
| CHEMBL517667 | — | — | 1 | 4.81 |
| CHEMBL476455 | — | — | 1 | 4.80 |
| CHEMBL476601 | — | — | 1 | 4.78 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.76 |
| CHEMBL498590 | — | — | 1 | 4.66 |
| CHEMBL476622 | — | — | 1 | 4.62 |
| CHEMBL387599 | — | — | 1 | 4.56 |
| CHEMBL504452 | — | — | 1 | 4.47 |
| CHEMBL478899 | — | — | 1 | 4.41 |
| CHEMBL478482 | — | — | 1 | 4.33 |
| CHEMBL476218 | — | — | 1 | 4.30 |
| CHEMBL477054 | — | — | 1 | 4.02 |
| CHEMBL477053 | — | — | 1 | - |
| CHEMBL129134 | — | — | 1 | - |
| CHEMBL476826 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476846 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL255963 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL478689 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL517667 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL476455 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL476601 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL140 | CURCUMIN | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL498590 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL476622 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL387599 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL504452 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL478899 | — | IC50 | = | 39100.0 | nM | 4.41 |
| CHEMBL478482 | — | IC50 | = | 46300.0 | nM | 4.33 |
| CHEMBL476218 | — | IC50 | = | 49900.0 | nM | 4.30 |
| CHEMBL477054 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL477053 | — | IC50 | = | 161000.0 | nM | - |
| CHEMBL129134 | — | IC50 | = | 217000.0 | nM | - |
| CHEMBL476826 | — | IC50 | = | 249000.0 | nM | - |