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Assay Detail

CHEMBL961805

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Binding
Inhibition of Escherichia coli thymidine phosphorylase
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Thymidine phosphorylase (CHEMBL3726)
Type SINGLE PROTEIN
Organism Escherichia coli K-12

Publication

Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors.
Khan KM, Ambreen N, Hussain S, Perveen S, Choudhary MI.
Bioorg Med Chem (2009) 17 : 2983 -2988
PubMed 19329330 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.84 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL65375 TIPIRACIL HYDROCHLORIDE 4.0 1 7.46
CHEMBL489635 1 4.72
CHEMBL86905 1 4.72
CHEMBL491260 1 4.70
CHEMBL122899 7-DEAZAXANTHINE 1 4.41
CHEMBL490045 1 4.39
CHEMBL524686 1 4.17
CHEMBL490853 1 4.12
CHEMBL490854 1 -
CHEMBL519335 1 -
CHEMBL483872 1 -
CHEMBL457577 1 -
CHEMBL484886 1 -
CHEMBL519521 1 -
CHEMBL489046 1 -
CHEMBL491261 1 -
CHEMBL453992 1 -
CHEMBL491259 1 -
CHEMBL489045 1 -
CHEMBL489044 1 -
CHEMBL490855 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL65375 TIPIRACIL HYDROCHLORIDE IC50 = 35.0 nM 7.46
CHEMBL489635 IC50 = 19000.0 nM 4.72
CHEMBL86905 IC50 = 19000.0 nM 4.72
CHEMBL491260 IC50 = 19770.0 nM 4.70
CHEMBL122899 7-DEAZAXANTHINE IC50 = 39280.0 nM 4.41
CHEMBL490045 IC50 = 40290.0 nM 4.39
CHEMBL524686 IC50 = 67320.0 nM 4.17
CHEMBL490853 IC50 = 75930.0 nM 4.12
CHEMBL490854 IC50 - -
CHEMBL519335 IC50 - -
CHEMBL483872 IC50 - -
CHEMBL457577 IC50 = 340010.0 nM -
CHEMBL484886 IC50 = 472600.0 nM -
CHEMBL519521 IC50 - -
CHEMBL489046 IC50 - -
CHEMBL491261 IC50 - -
CHEMBL453992 IC50 = 145560.0 nM -
CHEMBL491259 IC50 - -
CHEMBL489045 IC50 = 149780.0 nM -
CHEMBL489044 IC50 = 480210.0 nM -
CHEMBL490855 IC50 - -