Assay Detail
Binding
CHEMBL961810
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125]IABN from human D3 receptor expressed in HEK293 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 8.72 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424294 | — | — | 1 | 9.72 |
| CHEMBL1627321 | — | — | 1 | 9.59 |
| CHEMBL125916 | — | — | 1 | 9.49 |
| CHEMBL1627323 | — | — | 1 | 9.36 |
| CHEMBL1627322 | — | — | 1 | 9.29 |
| CHEMBL68740 | — | — | 1 | 9.28 |
| CHEMBL182379 | — | — | 1 | 9.14 |
| CHEMBL139926 | — | — | 1 | 9.09 |
| CHEMBL59725 | — | — | 1 | 9.09 |
| CHEMBL124444 | — | — | 1 | 9.04 |
| CHEMBL175734 | — | — | 1 | 8.96 |
| CHEMBL1627306 | — | — | 1 | 8.95 |
| CHEMBL1627314 | — | — | 1 | 8.92 |
| CHEMBL1627305 | — | — | 1 | 8.86 |
| CHEMBL1627308 | — | — | 1 | 8.85 |
| CHEMBL184383 | — | — | 1 | 8.80 |
| CHEMBL1627310 | — | — | 1 | 8.79 |
| CHEMBL366904 | — | — | 1 | 8.68 |
| CHEMBL1627315 | — | — | 1 | 8.63 |
| CHEMBL1627311 | — | — | 1 | 8.62 |
| CHEMBL1627304 | — | — | 1 | 8.58 |
| CHEMBL1627313 | — | — | 1 | 8.44 |
| CHEMBL1627320 | — | — | 1 | 8.34 |
| CHEMBL1627312 | — | — | 1 | 8.28 |
| CHEMBL1627316 | — | — | 1 | 8.21 |
| CHEMBL1627317 | — | — | 1 | 8.12 |
| CHEMBL1627319 | — | — | 1 | 8.12 |
| CHEMBL1627318 | — | — | 1 | 8.11 |
| CHEMBL1627324 | — | — | 1 | 7.95 |
| CHEMBL1627307 | — | — | 1 | 7.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424294 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL1627321 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL125916 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL1627323 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL1627322 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL68740 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL182379 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL139926 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL59725 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL124444 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL175734 | — | Ki | = | 1.11 | nM | 8.96 |
| CHEMBL1627306 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL1627314 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1627305 | — | Ki | = | 1.39 | nM | 8.86 |
| CHEMBL1627308 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL184383 | — | Ki | = | 1.59 | nM | 8.80 |
| CHEMBL1627310 | — | Ki | = | 1.61 | nM | 8.79 |
| CHEMBL366904 | — | Ki | = | 2.11 | nM | 8.68 |
| CHEMBL1627315 | — | Ki | = | 2.32 | nM | 8.63 |
| CHEMBL1627311 | — | Ki | = | 2.41 | nM | 8.62 |
| CHEMBL1627304 | — | Ki | = | 2.61 | nM | 8.58 |
| CHEMBL1627313 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1627320 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL1627312 | — | Ki | = | 5.21 | nM | 8.28 |
| CHEMBL1627316 | — | Ki | = | 6.11 | nM | 8.21 |
| CHEMBL1627317 | — | Ki | = | 7.51 | nM | 8.12 |
| CHEMBL1627319 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL1627318 | — | Ki | = | 7.71 | nM | 8.11 |
| CHEMBL1627324 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL1627307 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL1627309 | — | Ki | = | 62.1 | nM | 7.21 |